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"Oh, flames of purity, raze this corrupt city!"
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George Yamada (ジョージ山田 Jōji Yamada) is a Japanese-American soldier who is sent on a mission to assassinate Akira and Tetsuo Shima in the latter-half of the story, after Akira has levelled Neo-Tokyo. George Yamada plans to kill them with darts containing a biological poison. He is a lieutenant, and he is later joined by a team of U.S. Marines to carry out the mission at the Olympic Stadium after it becomes the headquarters for the Great Tokyo Empire.

However, the biochemical weapons fail to harm Tetsuo, instead giving him temporary control of his expanding powers again (for example Tetsuo restores his missing arm). Tetsuo proceeds to kill Yamada.