Shotaro Kaneda is the main protagonist of the manga. He is the leader of the Capsules and a friend of Tetsuo.
He vows to kill Tetsuo after he begins to change and kills friends of his because of the experiments he has been subjected to. He also meets Kei and becomes her boyfriend.
He witnesses the changes in Tetsuo and confronts him. He survives the events surrounding Akira and creates with his new friends a new empire. under his leadership and with the support of his dead friends, Neo-Tokyo is rebuilt.